Effexor drug interactions

Effexor is otherwise known as Venlafaxine. It is an antidepressant which is used to control anxiety, panic disorder and depression, by working on the central nervous system. Just like any other antidepressant, Effexor also has some side effects. Hence it is taken as per the doctor's prescription. Alternately, a medication guide will aid you regarding the dosage of Effexor. Needless to say, the dosage varies from person to person, depending on the individual's health conditions.

However, it is essential to know that Effexor interacts with certain drugs. Such interactions may cause side effects or may not give desired results. Rarely, Effexor drug interactions may be even fatal. Your doctor or pharmacist must be consulted to know the Effexor drug interactions. At this juncture, you must inform your doctor about the medications or treatments that you are presently undergoing. Also, inform your doctor about your liver or kidney problems, if any. Anyway, you must not start, stop or alter the dosage without consulting a doctor, since it may cause side effects.


MAO inhibitors like tranylcypromine, furazolidone, rasagiline, isocarboxazid, phenelzine, linezolid, procarbazine, moclobemide and selegiline, must not be taken along with Effexor, since it causes serious drug interaction. It must be stopped at least 2 weeks before using Effexor and while using Effexor. In addition, it should not be used for at least 7 days after the last dose of Effexor.

Effexor must not be used with weight loss products or drugs like phentermine and sibutramine. Also, it must not be taken along with tryptophan. These drugs interact with Effexor and are found to be fatal.

There are some drugs, which when used with Effexor alter one's heart rhythm. Macrolide antibiotics like erythromycin, amiodarone, sotalol, procainamide, quinidine, thioridazine, dofetilide and pimozide are few drugs that cause QT prolongation. Hence, it is vital to inform your doctor if you were using any of these drugs. In fact, it is advisable to carry all the prescriptions of the medications that you are undergoing. This will help your doctor in judging your health condition and so, he will be able to prescribe Effexor accordingly. It is necessary to inform your doctor even if you are taking any herbal product.

Nevertheless, there are few other medications that interact with Effexor and cause adverse effects. Do not fail to tell your doctor if you were taking drugs that could cause bleeding or bruising. Since, these drugs interact with Effexor and increase the risk of bleeding. For instance, drugs like aspirin, 'blood thinners' like heparin or warfarin, NSAIDs like ibuprofen and antiplatelet medicines like clopidogrel react with Effexor. In addition, do inform your doctor if you were using drugs that affect liver enzymes, since it removes Effexor from the body.

Besides this, the usage of HIV drugs like indinavir, tricyclic antidepressants which are otherwise known as TCAs like desipramine and antipsychotics like clozapine or haloperidol have to be notified to the doctor. Some drugs like muscle relaxants, anti-seizure drugs and psychiatric medicines should not to be taken along with Effexor as these drugs will increase the drowsiness.

In case you have been advised to take low-dose aspirin as a treatment for heart attack or for preventing stroke, then do continue the medication until your doctor recommends any change in your dosage, since the need for these medications overweigh the need for Effexor.

Besides these, notify your doctor if you are taking any other antidepressant drug since, Effexor should not be combined with other antidepressants. There are some drugs which are commonly used without any prescription. Antacids which treat extra stomach acid are one of the most common examples of such self medications. You must inform your physician about such self medications also. However, medications other than those listed above may interact with this medication.

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